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The most energy efficient reactions in physics, according to scientists

Energy efficiency in physics is not measured the way most people think about it. Instead of asking how much heat a process produces per unit of fuel, physicists often compare how much of a substance’s rest mass is converted directly into energy, using Einstein’s equation E=mc². By that mass-to-energy yardstick, the gap between everyday chemical reactions and the most extreme physical processes is staggering, spanning many orders of magnitude from the electron shuffles of combustion to the near-total conversion possible when matter meets antimatter.

Why Chemistry Barely Registers on the Scale

Every time someone strikes a match or burns natural gas, a chemical reaction takes place. Electrons rearrange between atoms, and electromagnetic energy is transferred in the process. That energy is real and useful, but measured against the total rest mass of the reactants, the fraction converted is vanishingly small. Chemistry deals with interactions among atoms, not among their nuclei, and as a result only an extremely tiny share of mass becomes energy, as described in an IOPscience textbook chapter on special relativity.

To put a number on it, chemical reactions typically liberate energy on the order of a few electron volts per reaction, meaning the fraction of rest mass converted to energy is extremely small compared with nuclear reactions. That figure is not a percentage of the fuel’s chemical energy; it is the fraction of the total mass-energy content, as defined by E=mc², that chemistry can access. The reason is straightforward: chemical bonds involve only the outermost electrons. The nucleus, which holds the overwhelming majority of an atom’s mass-energy, remains untouched. This is why scientists searching for the most efficient reactions in nature have always looked deeper, past the electron cloud and into the atomic nucleus itself.

Nuclear Fission and Fusion Unlock the Nucleus

Breaking into the nucleus changes the arithmetic dramatically. In fission, a heavy nucleus such as uranium splits into two approximately equal fragments, releasing significant energy. A single uranium fission event liberates roughly 170 MeV, a figure that is vastly greater than the energy yield of any chemical reaction, which operates on the scale of individual electron volts, according to a Springer review of nuclear fission. That difference of roughly eight orders of magnitude is what makes nuclear power plants so much more energy-dense than coal or gas plants, gram for gram.

Fusion goes further still. In a fusion reaction, two light nuclei merge to form a single heavier nucleus, as the U.S. Department of Energy explains. This is the process that powers the Sun and other stars. H. A. Bethe’s foundational paper, “Energy Production in Stars,” published in Physical Review, laid out the stellar energy-generation pathways, including the carbon-nitrogen-oxygen cycle, and established the physical basis for converting hydrogen to helium as an energy source. Fusion is more efficient than fission because a measurable fraction of the reactants’ rest mass, roughly 0.7% in the case of hydrogen-to-helium conversion, is transformed directly into energy. For practical context, researchers have reported progress toward fusion energy on Earth, aiming to reproduce the energy process that powers the stars under controlled laboratory conditions. Even so, 0.7% of rest mass is far from the theoretical ceiling.

Black Holes as Cosmic Energy Engines

One of the most efficient mass-to-energy conversion mechanisms discussed by astrophysicists does not involve nuclear reactions at all. When matter spirals into a black hole, gravitational and frictional forces heat the infalling material to extreme temperatures, and a substantial share of its mass radiates away as energy before crossing the event horizon. Accretion of matter onto black holes is an efficient way of converting mass into energy, much more so than nuclear fusion, which powers the light from stars, as described in a Nature commentary. In the most extreme cases, the efficiency of this process can approach a few tens of percent of the infalling matter’s rest mass, depending on the black hole’s spin and the geometry of the accretion disk, far outstripping the 0.7% ceiling of stellar fusion.

These accretion flows do not merely glow; they can emit across the electromagnetic spectrum, from radio waves to intense gamma rays. Observations of active galactic nuclei and related systems reveal that as matter orbits ever closer to the event horizon, it forms a hot, magnetized plasma that channels energy into powerful jets and high-energy radiation. For example, NASA analyses of gamma-ray emissions from the galaxy NGC 1068 show a distinct high-energy spectral bump attributed to processes near a central black hole, underscoring how effectively gravitational potential energy can be transformed into radiation. In terms of mass-to-energy conversion, these cosmic engines sit near the top of what general relativity allows, turning a substantial fraction of matter into pure energy before it disappears from view.

The Absolute Limit: Matter–Antimatter Annihilation

Beyond black hole accretion lies a conceptually simple, but practically elusive, ultimate benchmark for efficiency: annihilation of matter with antimatter. In this process, a particle and its antiparticle meet and are converted almost entirely into energy, typically in the form of high-energy photons. The efficiency of such a reaction, in the ideal case, is essentially 100% of the combined rest mass, making it the most energy-dense fuel imaginable by the standards of special relativity. Compared with the 0.1% efficiency of chemical reactions and the 0.7% efficiency of stellar fusion, annihilation stands apart as the theoretical pinnacle of mass-energy conversion.

To quantify this, consider Einstein’s formula E=mc² together with modern measurements of fundamental constants. The National Institute of Standards and Technology provides precise values for the atomic mass unit, which allows physicists to calculate exactly how much energy corresponds to a given amount of matter. Converting just one gram of matter and one gram of antimatter into energy would release an enormous amount of energy by everyday standards. Yet despite its allure, antimatter remains extraordinarily difficult to produce and store, and current technology can create only microscopic quantities at enormous energy cost. As a result, annihilation serves mainly as a theoretical yardstick, illustrating the ultimate limit that any physical process could reach when judged by the strict standard of mass-energy efficiency.

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*This article was researched with the help of AI, with human editors creating the final content.